Decision Production-- A Step Toward a Theory of Managerial Information Requi rements

The lack of a general theory of managerial information requirements is proposed as an underlying cause of the many MIS failures. This paper takes a first step toward developing such a theory. Viewing decision making as a production process (decisions being produced in much the same manner as normal goods or services), microeconomic concepts are employed to provide descriptive and normative guidance for the development of MIS

Identifying Appropriate MIS/DSS Support: A Cost Analysis Approach

This paper describes a microeconomic theory-based tool, called cost analysis, which can be used in MIS research to develop guidance for systems analysts and information resource managers. An example of this guidance is a matrix of decision making contexts versus appropriate MIS/DSS support. Systems analysts can use this matrix to help identify appropriate MIS/DSS design alternatives. Information resource managers can use this matrix to help plan for the proper evolution of MIS/DSS support

A contingent cost analysis of alternative manufacturing information systems

The evaluation of alternative management information systems can aid systems analysts determine appropriate information support for managers, aid managers to become informed participants in the system design process, and aid the planning of information systems in response to changes in the firm. Synthesizing microeconomic and contingency theories, this paper performs a cost analysis of two popular manufacturing information systems. The relative cost-effectiveness of these two systems is hypothesized and then validated using a random survey of manufacturing firms across the USA. A logistical regression of the data provides estimates of the relative information system cost-effectiveness in various manufacturing contexts.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26585/1/0000126.pd

Review of management information systems research: A management support emphasis

This article organizes, describes, and evaluates MIS research from 1981 through 1985 in order to provide an understanding of what constitutes MIS research and to indicate potentially rich areas for future research. The review emphasizes information systems research in support of management decision making as opposed, for example, to research into the management of information resources or the development of strategic information systems.Preliminary work includes developing a definition of MIS, adopting an organizing framework, and choosing journals for review. Once this foundation is laid, MIS research content and methodology up to 1980 are summarized based upon the findings of the First International Conference on Information Systems. Finally, MIS research from 1981 to 1985 is described and evaluated in terms of content and methodology.It was found that more progress has been made in identifying appropriate research questions than in answering those questions. Significant progress in generating answers may be made in the future due to a healthy shift in the choice of methodologies (shift from more speculative-conceptual to more theory-based/theory-generating empirical). However, progress toward developing a global notion (theory) of MIS seems relatively slow. This lack of progress seems to be a symptom of: - Lack of progress in defining the product of MIS (information). - Too much research focus upon what relationships exist instead of focusing upon why relationships exist. - Underlying problems in the natural sciences paradigm currently associated with MIS research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27465/1/0000506.pd

Communicating MIS research: A citation study of journal influence

Due to difficulties with objectively evaluating the quality of MIS research, attitudes about journals in which this research is published play an important role in determining the allocation of research resources. To provide a more objective basis for these attitudes, we examine journal influence in communicating MIS research over a 9-year period using citation analyses, researcher perceptions, and publishing patterns of top MIS research universities. As a result of these analyses, we identify a cohesive stable group of highly influential journals which can reasonably be called an MIS core. An internal ranking of this core is then determined which is significantly different from prior rankings.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31049/1/0000726.pd

Consensus Statement on the Terminology and Classification of Central Neck Dissection for Thyroid Cancer

Background: The primary goals of this interdisciplinary consensus statement are to review the relevant anatomy of the central neck compartment, to identify the nodal subgroups within the central compartment commonly involved in thyroid cancer, and to define a consistent terminology relevant to the central compartment neck dissection. Summary: The most commonly involved central lymph nodes in thyroid carcinoma are the prelaryngeal (Delphian), pretracheal, and the right and left paratracheal nodal basins. A central neck dissection includes comprehensive, compartment-oriented removal of the prelaryngeal and pretracheal nodes and at least one paratracheal lymph node basin. A designation should be made as to whether a unilateral or bilateral dissection is performed and on which side (left or right) in unilateral cases. Lymph node plucking or berry picking implies removal only of the clinically involved nodes rather than a complete nodal group within the compartment and is not recommended. A therapeutic central compartment neck dissection implies that nodal metastasis is apparent clinically (preoperatively or intraoperatively) or by imaging (clinically N1a). A prophylactic/elective central compartment dissection implies nodal metastasis is not detected clinically or by imaging (clinically N0). Conclusion: Central neck dissection at a minimum should consist of removal of the prelaryngeal, pretracheal, and paratracheal lymph nodes. The description of a central neck dissection should include both the indication (therapeutic vs. prophylactic/elective) and the extent of the dissection (unilateral or bilateral).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78103/1/thy.2009.0159.pd

Male gays in the female gaze: women who watch m/m pornography

This paper draws on a piece of wide-scale mixed-methods research that examines the motivations behind women who watch gay male pornography. To date there has been very little interdisciplinary research investigating this phenomenon, despite a recent survey by PornHub (one of the largest online porn sites in the world) showing that gay male porn is the second most popular choice for women porn users out of 25+ possible genre choices. While both academic literature and popular culture have looked at the interest that (heterosexual) men have in lesbian pornography, considerably less attention has been paid to the consumption of gay male pornography by women. Research looking at women's consumption of pornography from within the Social Sciences is very focused around heterosexual (and, to a lesser extent, lesbian) pornography. Research looking more generally at gay pornography/erotica (and the subversion of the ‘male gaze’/concept of ‘male as erotic object’) often makes mention of female interest in this area, but only briefly, and often relies on anecdotal or observational evidence. Research looking at women's involvement in slashfic (primarily from within media studies), while very thorough and rich, tends to view slash writing as a somewhat isolated phenomenon (indeed, in her influential article on women's involvement in slash, Bacon-Smith talks about how ‘only a small number’ of female slash writers and readers have any interest in gay literature or pornography more generally, and this phenomenon is not often discussed in more recent analyses of slash); so while there has been a great deal of very interesting research done in this field, little attempt has been made to couch it more generally within women's consumption and use of pornography and erotica or to explore what women enjoy about watching gay male pornography. Through a series of focus groups, interviews, and an online questionnaire (n = 275), this exploratory piece of work looks at what women enjoy about gay male pornography, and how it sits within their consumption of erotica/pornography more generally. The article investigates what this has to say about the existence and nature of a ‘female gaze’

A Liposome-Based Mycobacterial Vaccine Induces Potent Adult and Neonatal Multifunctional T Cells through the Exquisite Targeting of Dendritic Cells

BACKGROUND: In the search for more potent and safer tuberculosis vaccines, CAF01 was identified as a remarkable formulation. Based on cationic liposomes and including a synthetic mycobacterial glycolipid as TLR-independent immunomodulator, it induces strong and protective T helper-1 and T helper-17 adult murine responses to Ag85B-ESAT-6, a major mycobacterial fusion protein. Here, we assessed whether these properties extend to early life and how CAF01 mediates its adjuvant properties in vivo. METHODS/FINDINGS: Following adult or neonatal murine immunization, Ag85B-ESAT-6/CAF01 similarly reduced the post-challenge bacterial growth of M. bovis BCG, whereas no protection was observed using Alum as control. This protection was mediated by the induction of similarly strong Th1 and Th17 responses in both age groups. Multifunctional Th1 cells were already elicited after a single vaccine dose and persisted at high levels for at least 6 months even after neonatal priming. Unexpectedly, this potent adjuvanticity was not mediated by a massive targeting/activation of dendritic cells: in contrast, very few DCs in the draining lymph nodes were bearing the labeled antigen/adjuvant. The increased expression of the CD40 and CD86 activation markers was restricted to the minute portion of adjuvant-bearing DCs. However, vaccine-associated activated DCs were recovered several days after immunization. CONCLUSION: The potent adult and neonatal adjuvanticity of CAF01 is associated in vivo with an exquisite but prolonged DC uptake and activation, fulfilling the preclinical requirements for novel tuberculosis vaccines to be used in early life

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure